副教授

何晓燕

职称:副教授

学历:博士

邮箱:hexiaoyan@ahmu.edu.cn

地址:合肥市瑶海区玉皇山路,威廉william集团公司东校区,弘毅东楼

个人简介
2019.07-至今 威廉william集团公司,威廉william集团公司,校聘副教授
2014.09-2019.06 武汉大学化学与分子科学公司,硕博连读
2010.09-2014.06 湖北师范大学化学与化工公司,学士
科研领域
恶性肿瘤是威胁人类健康最主要的疾病之一,本实验室的研究工作主要聚焦于肿瘤的诊断和治疗方面。近期的研究方向主要集中于以下三点:1.新型药物和基因传递系统的研究;2.疾病的诊断和治疗新材料的开发;3.通过研究肿瘤的发生的机制、肿瘤微环境与肿瘤恶化的关系,探索一些新型的肿瘤治疗思路。
代表性成果

1. Li X#, Qiao L#, Wang W, Xiong Y, Zhang L, Shan G, Sun Q, Ding T, He X*. A Bispecific Nanobridge Derived from Immunogenic Tumor Membranes Restores Dendritic Cell-T Cell Crosstalk for Enhanced Solid Tumor Immunotherapy. ACS Nano. 2026, 20(41):27890-27907.

2. Shan G#, Wang W#, Li X, Zhai Z, Liu M, Peng R, Sun Q, Zhang H, Guo T, He X*. Epigenetic-targeted biomimetic nanomedicine modulates epithelial mesenchymal transition to enhance chemosensitivity in heterogeneous tumors. Biomaterials. 2026, 324:123529.

3. Wang W#, Mu S#, Zhang J#, Shan G, Li X, Wang R, Guo T*, He X*. Trojan Horse Strategy: How Biomimetic Nanomedicine Remodels the Tumor Microenvironment. Adv Sci (Weinh). 2026, 13(10):e19213.

4. Gao M#, Sun Q#, Zhang R#, Shan G, Zhang H, Peng R, Liu M, Sun G, Qiao L*, Li Y*,He X*. Extracellular vesicles-hitchhiking boosts the deep penetration of drugs to amplify anti-tumor efficacy. Biomaterials. 2025, 314:122829.

5. Qin W#, Qiao L#, Wang Q#, Gao M, Zhou M, Sun Q, Zhang H, Yang T, Shan G, Yao W, Yi X*, He X*. Advancing Precision: A Controllable Self-Synergistic Nanoplatform Initiating Pyroptosis-Base Immunogenic Cell Death Cascade for Targeted Tumor Therapy. ACS Nano 2024, 18(2):1582-1598.

6. Qiao L#, Gao M#, Yi X#, Peng H, Zhang R, Yao W, Sun G, He X*.Biomimetic gene editing system for precise tumor cell reprogramming and augmented tumor therapy. J Control Release 2023, 356:663-677.

7. Wang Q#, Qin W#, Qiao L#, Gao M, Zhou M, Zhang H, Sun Q, Yao W, Yang T, Ren X*, Sun G*, He X*.Biomimetic Nanophotosensitizer Amplifies Immunogenic Pyroptosis and Triggers Synergistic Cancer Therapy. Adv Healthc Mater 2023, 12(29):e2301641.

8. Gao M#, Yang T#, Qin W#, Wang Q, Peng H, Yao W, Yi X*, Sun G*,He X*, Cell membrane-anchoring nano-photosensitizer for light-controlled calcium-overload and tumor-specific synergistic therapy, Small 2022, 18(48):e2204689.

9. Peng H, Qiao L*, Shan G, Gao M, Zhang R, Yi X, He X*,Stepwise responsive carboxymethyl chitosan-based nanoplatform for effective drug-resistant breast cancer suppression, Carbohyd. Polym. 2022, 291, 119554.

10. Yang T#, Zhou M#, Gao M#, Qin W, Wang Q, Peng H, Yao W, Qiao L*, He X*. Carrier-Free H2O2 Self-Supplier for Amplified Synergistic Tumor Therapy. Small 2023, 19(7):e2205692.

11. Han D, Liao XR, Huang QY, Qi LJ, Xu C, Ren XH,He X*, Guo T, Huang Y*, Pang X, Chen X*, Zhang XZ*, Cheng SX*. Functional Delivery Systems for Targeting Tumor Heterogeneity: Reversing Immunosuppression and Modulating Cancer-Immune Interplay. ACS Nano. 2025, 19(22):20808-20823.

12. Han D, Ren X, Liao X, He X*, Guo T*, Chen X, Pang X, Cheng S*. A Multiple Targeting Nanoprobe for Identifying Cancer Metastatic Sites Based on Detection of Various mRNAs in Circulating Tumor Cells. Nano Lett. 2023, 23(9):3678-3686

13. .Ren X, Xu C, Li L, Zuo Y, Han D, He X*, Cheng S*, A targeting delivery system for effective genome editing in leukemia cells to reverse malignancy, J. Control. Release 2022, 343, 645-656.

14. Sun Q, Shan G, Wang W, Li X, Yan L, Peng R, Liu M, Huang X, Ren X,*He X*, Qiao L*. Reversing hypoxia-induced immune evasion in tumors to enhance cancer immunotherapy. J Control Release. 2025, 382, 113745.

15. Zhang W, Wu W, Wang T, Wu Z, Li Y, Ding T, Fang Z, Tian D, He X*, Huang F*.. Novel Supramolecular Hydrogel for Infected Diabetic Foot Ulcer Treatment. Adv Healthc Mater. 2024 Dec;13(31):e2402092. doi: 10.1002/adhm.202402092. Epub 2024 Sep 3. PMID: 39225408.


研究课题
1. 国家自然科学基金面上项目,2026.01-2029.12;82572392,主持;
2. 安徽省自然科学基金面上项目,2025.09-2028.08;2508085MH213,主持
3. 国家自然科学基金青年项目,2021.01-2023.12;52003006,主持
4. 安徽省自然科学基金青年项目,2020.07-2022.06;2008085QH382,主持
5. 安徽省高等公司科学研究项目重点项目,2026.01-2027.12;2025AHGXZK30924,主持
6. 威廉william集团公司引进人才科研启动项目,2019/09-2024/09,主持
7. 威廉william集团公司校科研启动项目,2020/01-2021/12,主持

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